Welcome to the LiSyM Network
Liver Systems Medicine, or LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety.
They want to answer questions about the origin and progression of the metabolic liver disease non-alcoholic fatty liver disease (NAFLD). What initiates NAFLD? How does it develop? How can we improve diagnosis and treatment? More about our work
In LiSyM, 37 research groups at 23 scientific centers and institutions located around Germany have joined forces to tackle some of the most complex problems of the human body. More about us
Research focuses on the four key, yet overlapping themes of the pillars. Four junior groups also address specific research topics.
Chronic Liver Disease ProgressionWhen connective tissue replaces functioning liver cells
Regeneration and Repair in Acute-on-Chronic Liver Failure (ACLF)Liver failure after a long illness: Can it be prevented? Can the liver recover?
Liver Function DiagnosticsDevelops computer-based diagnostic tools to help detect and assess changed liver functions early.
New Insights into Bile Secretion in the Liver
"Our new findings require a scientific debate in liver research, which will lead to an adjustment of the doctrine to the new observation. It is to be hoped that this will lead to long-term progress in the treatment of liver diseases", summarizes Dr. Nachiket Vartak, junior group leader in the LiSyM research program.
Press release (English):
Press release (German):
Publication: Vartak, N. et al.: Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux. Hepatology 2020. doi: 10.1002/hep.31422
Loss of hepatic MBOAT7 leads to liver fibrosis
Their study is based on the analysis of mice with hepatocyte-specific MBOAT7 deletion, of associations between the rs641738C>T genotype and liver inflammation and fibrosis in 846 NAFLD patients as well as genotype-specific liver lipidomes from 280 human biopsies.
See publication: https://gut.bmj.com/content/early/2020/06/25/gutjnl-2020-320853.long
The Holy Grail of Systems Biology
Only models that simulate biological systems on computers make it possible to assemble the existing mass of heterogeneous data into dynamic reproductions in a meaningful way. Mathematical models enable systems researchers to deliver results more quickly and successfully. The idea that digital computers can play an essential role in this research is older than the machines themselves.
Read the article
Better diagnosis of NAFLD with 3D model of human liver tissue
To press release
The LiSyM network continues to organize the biennial SBMC Conference. In 2020 the 8th SBMC Conference will take place in Heidelberg.
Research with liver tissue has a long tradition and has been the basis of the discipline of biochemistry. Over the years this research has yielded a wealth of stored quantifiable data. In Systems Medicine these data are re-used to integrate with new data as to develop multi-scale computational models that help in understanding the complexity of metabolism and its derangement in human diseases.
This should lead to a more personalised type of medicine, earlier diagnosis and new therapies